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Formulating with Lutein

Posted on May 4, 2022 by Jamie Marchetti

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colorful vegetables in separate containersLutein is an up-and-comer in the food formulation industry. Many people know of lutein as a component of egg yolks and as a critical player in healthy human eye retina function, as well as its antioxidant properties throughout various human organ systems and tissues.1 It has also been used as a food additive for its pigmenting properties: lutein lends a yellow or orange-red pigment to foods as it absorbs blue light.1 There are several formulation challenges, however.

Lutein belongs to the xanthophyll family of carotenoids and is found naturally in egg yolks, animal fats, and plants such as flowers, grains, fruits, and vegetables, including spinach and kale.2 The market for lutein is segmented into pharmaceuticals, dietary supplements, foods, and animal and fish feed industries. Typically, in pharmaceuticals, dietary supplements, and foods, lutein is partnered with zeaxanthin, which is a similar molecule and also provides antioxidant functions in the human body.3 These functions are the nutrition-related reasons that consumers would be inclined to purchase food items formulated with lutein.

Challenges to formulating using lutein

The challenges to formulation using lutein are several and largely related to its molecular instability:2

  • Heat from boiling, steaming, sauteing, or other methods in the processing of foods can cause de-esterification or cis/trans isomerization of lutein molecules.
  • Extreme pH outside of the range of 4.0-8.0 can also cause de-esterification or cis/trans isomerization of lutein molecules.
  • Light can cause the creation of colorless molecules of low molecular weight.
  • Oxygen presence causes lutein’s antioxidant properties to react.
  • Lutein is fat-soluble and water-insoluble.

Overcoming the challenges

There are some methods that help to overcome these formulation challenges with lutein:2

  • Freezing
  • Inclusion of antioxidants and exclusion of oxygen via vacuum sealing or airtight containers

There are products being made to improve the dispersion of lutein in water, such as a delivery method that uses a sucralose monolaurate emulsifier, which has been found to allow the addition of lutein to clear liquid beverages.4 

Recommended reading

  1. Lutein
  2. Lutein as a functional food ingredient: Stability and bioavailability
  3. Lutein and Zeaxanthin: Benefits, Dosage, and Food Sources
  4. New lutein fortified formulations to market

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Filed Under: Featured, Food, Beverage & Nutrition

About Jamie Marchetti

Jamie M. Marchetti, MS, RDN, LD is a clinical dietitian in Gillette, Wyoming, as well as a freelance writer, and a nutrition/wellness blogger at ScintillaLife.com. Her favorite pastimes include fitness, crocheting, dancing, and learning fetch from her dog, Gus.
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